Abstract | CONTEXT: Gastric adenocarcinoma (GAC) is a common malignancy with high mortality-rate. Analysis of molecular markers could form a foundation for the future use of targeted therapies to reduce morbidity and mortality. AIMS: MATERIALS AND METHODS: A total of 100 cases of GAC diagnosed over a 2 year period were studied. Expression of E-cadherin and HER-2/neu was analyzed by IHC in relation to the histological type and grade. RESULTS: Of the 100 cases of GAC studied, 11 revealed a loss of E-cadherin and over-expression of HER-2/neu was seen in 17 cases. Loss of E-cadherin was seen in 50% of signet ring-cell carcinomas but only in 8% of tubular and none of papillary and mucin-secreting GAC (P = 0.003). Of all the cases of tubular GAC with loss of E-cadherin expression, majority (71.4%) were Grade III (P = 0.04). Of all the tubular GAC cases with an over-expression of HER-2/neu, 20% and 67% were Grade I and II GAC respectively while only 13% were Grade III (P < 0.001). CONCLUSIONS:
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Authors | Khushboo Dewan, Renu Madan, Prasanta Sengupta, Reena Bharadwaj |
Journal | Indian journal of pathology & microbiology
(Indian J Pathol Microbiol)
2015 Apr-Jun
Vol. 58
Issue 2
Pg. 154-7
ISSN: 0974-5130 [Electronic] India |
PMID | 25885125
(Publication Type: Journal Article)
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Chemical References |
- Cadherins
- ERBB2 protein, human
- Receptor, ErbB-2
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Topics |
- Adenocarcinoma
(diagnosis, pathology)
- Adult
- Aged
- Aged, 80 and over
- Cadherins
(analysis)
- Female
- Humans
- Immunohistochemistry
(methods)
- Male
- Middle Aged
- Receptor, ErbB-2
(analysis)
- Severity of Illness Index
- Stomach Neoplasms
(diagnosis, pathology)
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