Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats.

Abstract

Groups of 10 goats, harbouring both naturally acquired and experimental infections of gastrointestinal nematodes, were drenched with either levamisole (5 mg kg-1), albendazole (3.8 mg kg-1) or parbendazole (15 mg kg-1), or remained untreated. Haemonchus contortus was the numerically dominant infection, with Strongyloides papillosus, Trichostrongylus colubriformis and Oesophagostomum columbianum also present. At 5-6 days post-treatment, goats were killed and necropsied. Post-mortem worm counts showed that the reduction in mean total worm burdens was 57.4% in levamisole-treated animals, 71.1% in the albendazole group and 85.1% in the parbendazole group. Reductions for H. contortus were 80.2, 87.9 and 83.9% in the levamisole-, albendazole- and parbendazole-treated groups, respectively. These data indicate that the anthelmintics in question are not being applied at an adequate dose rate for goats, and/or resistance to anthelmintics is occurring in the field in Pernambuco State, northeast Brazil.

• Authors: T P Charles, J Pompeu, D B Miranda
• Journal: Veterinary parasitology (Vet Parasitol) Vol. 34 Issue 1-2 Pg. 71-5 (Nov 1989) ISSN: 0304-4017 [Print] NETHERLANDS
• PMID: 2588471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics
• Benzimidazoles
• Levamisole
• Albendazole
• parbendazole

Topics

• Albendazole (therapeutic use)
• Animals
• Anthelmintics (therapeutic use)
• Benzimidazoles (therapeutic use)
• Brazil
• Goat Diseases (drug therapy)
• Goats
• Intestinal Diseases, Parasitic (drug therapy, veterinary)
• Levamisole (therapeutic use)
• Male
• Nematode Infections (drug therapy, veterinary)
• Random Allocation