Efficacy of three broad-spectrum anthelmintics against gastrointestinal nematode infections of goats.

Groups of 10 goats, harbouring both naturally acquired and experimental infections of gastrointestinal nematodes, were drenched with either levamisole (5 mg kg-1), albendazole (3.8 mg kg-1) or parbendazole (15 mg kg-1), or remained untreated. Haemonchus contortus was the numerically dominant infection, with Strongyloides papillosus, Trichostrongylus colubriformis and Oesophagostomum columbianum also present. At 5-6 days post-treatment, goats were killed and necropsied. Post-mortem worm counts showed that the reduction in mean total worm burdens was 57.4% in levamisole-treated animals, 71.1% in the albendazole group and 85.1% in the parbendazole group. Reductions for H. contortus were 80.2, 87.9 and 83.9% in the levamisole-, albendazole- and parbendazole-treated groups, respectively. These data indicate that the anthelmintics in question are not being applied at an adequate dose rate for goats, and/or resistance to anthelmintics is occurring in the field in Pernambuco State, northeast Brazil.
AuthorsT P Charles, J Pompeu, D B Miranda
JournalVeterinary parasitology (Vet Parasitol) Vol. 34 Issue 1-2 Pg. 71-5 (Nov 1989) ISSN: 0304-4017 [Print] NETHERLANDS
PMID2588471 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthelmintics
  • Benzimidazoles
  • Levamisole
  • Albendazole
  • parbendazole
  • Albendazole (therapeutic use)
  • Animals
  • Anthelmintics (therapeutic use)
  • Benzimidazoles (therapeutic use)
  • Brazil
  • Goat Diseases (drug therapy)
  • Goats
  • Intestinal Diseases, Parasitic (drug therapy, veterinary)
  • Levamisole (therapeutic use)
  • Male
  • Nematode Infections (drug therapy, veterinary)
  • Random Allocation

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