Abstract | BACKGROUND: Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success. PATIENT DESCRIPTION: We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen. CONCLUSION:
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Authors | Dimah Saade, Charuta Joshi |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 52
Issue 5
Pg. 544-7
(May 2015)
ISSN: 1873-5150 [Electronic] United States |
PMID | 25882081
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticonvulsants
- Cannabidiol
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Topics |
- Anticonvulsants
(therapeutic use)
- Cannabidiol
(therapeutic use)
- Electroencephalography
- Epilepsies, Partial
(drug therapy)
- Humans
- Infant
- Male
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