Wilms tumor 1 (WT1) protein: Diagnostic utility in pediatric tumors.

Abstract

Despite Wilms tumor 1 (WT1) protein was originally considered as a specific immunomarker of Wilms tumor, with the increasing use of immunohistochemistry, there is evidence that other tumors may share WT1 protein expression. This review focuses on the immunohistochemical profile of WT1 protein in the most common malignant tumors of children and adolescents. The variable expression and distribution patterns (nuclear vs cytoplasmic) in the different tumors, dependent on the antibodies used (anti-C or N-terminus WT1 protein), will be emphasized by providing explicative illustrations. Potential diagnostic pitfalls from unexpected WT1 protein expression in some tumors will be discussed in order to avoid diagnostic errors, especially when dealing with small biopsies.

• Authors: Lucia Salvatorelli, Rosalba Parenti, Giorgia Leone, Giuseppe Musumeci, Enrico Vasquez, Gaetano Magro
• Journal: Acta histochemica (Acta Histochem) 2015 May-Jun Vol. 117 Issue 4-5 Pg. 367-78 ISSN: 1618-0372 [Electronic] Germany
• PMID: 25881478 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor
• WT1 Proteins
• WT1 protein, human

Topics

• Adolescent
• Biomarkers, Tumor (immunology, metabolism)
• Child
• Child, Preschool
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• WT1 Proteins (biosynthesis, immunology)
• Wilms Tumor (diagnosis, immunology, metabolism, pathology)