[Autoimmune reactions against interleukin-2 receptors in patients with blood system diseases and in experimental Rauscher retrovirus leukemia].

Abstract

Apart from autoimmune reactions, antibodies to IL-2 receptors were identified in blood sera of linear mice during leukemogenesis. It is indicated that in the course of leukemia establishment, there can be demonstrated antibodies capable of blocking IL-2 receptors on the membrane of activated T lymphocytes and inhibiting IL-2-dependent proliferation of T cells. The blood sera of patients suffering from chronic lymphoid leukemia, acute lymphoblastic leukemia, lymphocytomas, pure red-cell aplasia, and aplastic anemia showed antibodies against IL-2 receptors. Out of the total number of 52 patients, 23 demonstrated those antibodies. The data obtained should be taken into account in the patients' management using IL-2.

• Authors: V S Ter-Grigorov, A V Pivnik, V A Novikov, Z Kh Mamiliaeva, O Ia Moskovkina
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 61 Issue 7 Pg. 44-8 ( 1989) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: Autoimmunnye reaktsii protiv retseptorov dlia interleĭkina-2 u bol'nykh s nekotorymi zabolevaniiami sistemy krovi i pri éksperimental'nom retrovirusnom leĭkoze Raushera.
• PMID: 2588142 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antigen-Antibody Complex
• Autoantibodies
• Receptors, Interleukin-2

Topics

• Adult
• Animals
• Antigen-Antibody Complex (analysis)
• Antigen-Antibody Reactions (immunology)
• Autoantibodies (analysis)
• Autoimmune Diseases (etiology, immunology)
• Female
• Hematologic Diseases (etiology, immunology)
• Humans
• Leukemia, Experimental (etiology, immunology)
• Mice
• Rauscher Virus
• Receptors, Interleukin-2 (analysis, immunology)
• T-Lymphocytes (immunology)