ATM kinase sustains HER2 tumorigenicity in breast cancer.

Abstract	ATM kinase preserves genomic stability by acting as a tumour suppressor. However, its identification as a component of several signalling networks suggests a dualism for ATM in cancer. Here we report that ATM expression and activity promotes HER2-dependent tumorigenicity in vitro and in vivo. We reveal a correlation between ATM activation and the reduced time to recurrence in patients diagnosed with invasive HER2-positive breast cancer. Furthermore, we identify ATM as a novel modulator of HER2 protein stability that acts by promoting a complex of HER2 with the chaperone HSP90, therefore preventing HER2 ubiquitination and degradation. As a consequence, ATM sustains AKT activation downstream of HER2 and may modulate the response to therapeutic approaches, suggesting that the status of ATM activity may be informative for the treatment and prognosis of HER2-positive tumours. Our findings provide evidence for ATM's tumorigenic potential revising the canonical role of ATM as a pure tumour suppressor.
Authors	Venturina Stagni, Isabella Manni, Veronica Oropallo, Marcella Mottolese, Anna Di Benedetto, Giulia Piaggio, Rita Falcioni, Danilo Giaccari, Selene Di Carlo, Francesca Sperati, Maria Teresa Cencioni, Daniela Barilà
Journal	Nature communications (Nat Commun) Vol. 6 Pg. 6886 (Apr 16 2015) ISSN: 2041-1723 [Electronic] England
PMID	25881002 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	HSP90 Heat-Shock Proteins ERBB2 protein, human Receptor, ErbB-2 ATM protein, human Ataxia Telangiectasia Mutated Proteins Proto-Oncogene Proteins c-akt
Topics	Adult Aged Aged, 80 and over Animals Ataxia Telangiectasia Mutated Proteins (genetics, metabolism) Breast Neoplasms (genetics, metabolism) Carcinogenesis (genetics) Carcinoma (genetics, metabolism) Case-Control Studies Cell Line, Tumor Female HEK293 Cells HSP90 Heat-Shock Proteins (metabolism) Humans Immunohistochemistry In Vitro Techniques MCF-7 Cells Mice Mice, Transgenic Middle Aged Neoplasm Transplantation Proto-Oncogene Proteins c-akt (metabolism) Receptor, ErbB-2 (genetics, metabolism) Young Adult

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