Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study.

Abstract

BACKGROUND:

To estimate the disability-adjusted life years (DALY) in a nationwide representative sample of postmenopausal women with osteoporosis. The effects of drug-based therapy and risk factors for osteoporotic bone fractures on DALY losses were also explored.

METHODS:

DALY were estimated based on participant's clinical characteristics and Health-Related Quality-of-Life (HRQoL) data obtained from a cross-sectional, epidemiological one-visit study (the GINERISK study). The study enrolled postmenopausal women (at least 12-months after their last menstrual period) with osteoporosis, above 18-years old, who attended Spanish outpatient Gynaecology clinics. HRQoL was assessed using the generic SF-12v2 questionnaire, which was used to derive disutility values. Mortality rates were extracted from the Spanish national statistics database. Factors explored to be associated with DALY losses were examined using ANOVA, ANCOVA and MANCOVA models.

RESULTS:

DALY could be computed in 2,782 (67%) out of 4,157 postmenopausal women, with a mean (95% CI) age of 61.0 (60.7-61.2) years. Overall individual undiscounted DALY per woman were 6.1 (5.9-6.2), resulting to be significantly higher in women with severe osteoporosis with prior bone fracture; 7.8 (7.2-8.4) compared to osteoporotic women [5.8 (5.6-6.0)] or postmenopausal women with a BMD > -2.5 T-score that received a drug-based therapy [6.2 (5.8-6.5)]; F = 27.0 (P < 0.01). Models explaining the variation in the levels of health based on the use of a selective estrogen receptor modulator (SERM) or possession of risk factors for osteoporotic BF were found (P < 0.05).

CONCLUSIONS:

DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses.

• Authors: Josep Darbà, Lisette Kaskens, Nuria Pérez-Álvarez, Santiago Palacios, José Luis Neyro, Javier Rejas
• Journal: BMC public health (BMC Public Health) Vol. 15 Pg. 324 (Apr 02 2015) ISSN: 1471-2458 [Electronic] England
• PMID: 25880810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bone Density Conservation Agents

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Bone Density
• Bone Density Conservation Agents (administration & dosage)
• Comorbidity
• Cost of Illness
• Cross-Sectional Studies
• Disabled Persons
• Exercise
• Female
• Health Behavior
• Humans
• Middle Aged
• Osteoporosis (drug therapy, economics, epidemiology)
• Osteoporosis, Postmenopausal (drug therapy, economics, epidemiology)
• Osteoporotic Fractures (epidemiology)
• Quality-Adjusted Life Years
• Risk Factors
• Socioeconomic Factors
• Spain (epidemiology)
• Time Factors