Guillain-Barre syndrome (GBS) is rarely reported in children with
acute lymphoblastic leukemia (ALL) and may be difficult to differentiate from
vincristine induced neuropathy. Only few case reports highlighted GBS with ALL. We report a 10-year-old male child who was a diagnosed case of ALL since 3 month on
chemotherapy. At 3(rd) week of
chemotherapy, he developed rapidly progressive ascending motor
quadriparesis over 2 days. Clinical and electrophysiology revealed acute motor axonal neuropathy (
AMAN) variant of GBS. He was treated with
intravenous immunoglobulin (2 g/kg) without discontinuing
chemotherapy. Complete recovery took 12 weeks despite
immunotherapy, and it was corroborating to slow remission. We concluded that
AMAN variant is usually present in B-cell type ALL, may be causal for GBS and it takes 6-16 weeks to complete recovery which may correspond to remission of ALL. However, it needs to be studied. We also present a meta-analysis of previously reported cases of GBS in ALL.