The prevalence of hospital strains of P. aeruginosa, A. baumannii and K. pneumoniae characterizing by multiple drug resistance to overwhelming majority of
antibiotics anew evoked an increased interest to
colistin. However, until now there is not enough information concerning pharmacokinetics of
colistin to optimize dosage of this
pharmaceutical. The study was carried out to analyze pharmacokinetics of both
colistin and
sodium colistimitate in children with chemically induced
neutropenia. To quantitatively detect
colistin in blood serum the technique of highly effective fluid chromatography with mass spectrometry was applied. The concentration of
colistin was detected in 21 children with chemically induced
neutropenia (13 patients with
septicemia, 8 children of control group) after
intravenous injection of
sodium colistimitate. The significant variability of pharmacokinetic parameters of
colistin was established both in patients with
septicemia and in control group. The technique of highly effective fluid chromatography with mass spectrometry can be applied for therapeutic medicinal monitoring and optimization regimen of dosage.