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Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation.

Abstract
Kaempferol is a natural flavonoid found in many vegetables and fruits. Epidemiologic studies have described that Kaempferol intake could reduce risk of cancer, especially lung, gastric, pancreatic and ovarian cancers. Recent studies have shown that Kaempferol could also be beneficial to the body to defend against inflammation, and infection by bacteria and viruses; however, the molecular mechanism of its immunoregulatory function remains largely unknown. Through screening a small molecule library of traditional Chinese medicine (TCM), we identified that Kaempferol could enhance the suppressive function of regulatory T cells (Tregs). Kaempferol was found to increase FOXP3 expression level in Treg cells and prevent pathological symptoms of collagen-induced arthritis in a rat animal model. Kaempferol could also reduce PIM1-mediated FOXP3 phosphorylation at S422. Our study reveals a molecular mechanism that underlies the anti-inflammatory action of Kaempferol for the prevention and treatment of inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus, and ankylosing spondylitis.
AuthorsFang Lin, Xuerui Luo, Andy Tsun, Zhiyuan Li, Dan Li, Bin Li
JournalInternational immunopharmacology (Int Immunopharmacol) Vol. 28 Issue 2 Pg. 859-65 (Oct 2015) ISSN: 1878-1705 [Electronic] Netherlands
PMID25870037 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • FOXP3 protein, human
  • Forkhead Transcription Factors
  • Foxp3 protein, rat
  • Kaempferols
  • RNA, Messenger
  • kaempferol
  • Proto-Oncogene Proteins c-pim-1
Topics
  • Animals
  • Anti-Inflammatory Agents (pharmacology, therapeutic use)
  • Arthritis, Experimental
  • Arthritis, Rheumatoid (drug therapy, immunology, pathology)
  • Female
  • Forkhead Transcription Factors (genetics, immunology)
  • HEK293 Cells
  • Humans
  • Jurkat Cells
  • Kaempferols (pharmacology, therapeutic use)
  • Phosphorylation (drug effects)
  • Proto-Oncogene Proteins c-pim-1 (immunology)
  • RNA, Messenger (metabolism)
  • Rats, Wistar
  • T-Lymphocytes, Regulatory (drug effects, immunology)

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