ACG Clinical Guideline: Primary Sclerosing Cholangitis.

Abstract

Primary sclerosing cholangitis is a chronic cholestatic liver disease that can shorten life and may require liver transplantation. The cause is unknown, although it is commonly associated with colitis. There is no approved or proven therapy, although ursodeoxycholic acid is used by many on an empiric basis. Complications including portal hypertension, fat-soluble vitamin deficiency, metabolic bone diseases, and development of cancers of the bile duct or colon can occur.

• Authors: Keith D Lindor, Kris V Kowdley, M Edwyn Harrison, American College of Gastroenterology
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 110 Issue 5 Pg. 646-59; quiz 660 (May 2015) ISSN: 1572-0241 [Electronic] United States
• PMID: 25869391 (Publication Type: Journal Article, Practice Guideline)

Chemical References

• Anti-Infective Agents
• Cholagogues and Choleretics
• Immunosuppressive Agents
• Ursodeoxycholic Acid

Topics

• Anti-Infective Agents (therapeutic use)
• Cholagogues and Choleretics (therapeutic use)
• Cholangiopancreatography, Endoscopic Retrograde
• Cholangitis, Sclerosing (complications, diagnosis, epidemiology, therapy)
• Digestive System Neoplasms (diagnosis)
• Gallstones
• Humans
• Immunosuppressive Agents (therapeutic use)
• Inflammatory Bowel Diseases (diagnosis, epidemiology)
• Liver Transplantation
• Ursodeoxycholic Acid (therapeutic use)