HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Successful pregnancy and breastfeeding in a woman with mucopolysaccharidosis type I while receiving laronidase enzyme replacement. therapy.

Abstract
The authors describe the first mother-infant pair to complete an on-going, prospective, open-label, Phase 4 trial (ALIU) UU3, NCT00418821) determining the safety of laronidase enzyme replacement therapy (ERT) in pregnant women with mucopolysaccharidosis type I (MPS I) and their breastfed infants. The mother, a 32-year-old with attenuated MPS I (Scheie syndrome), received laronidase for three years and continued treatment throughout her second pregnancy and while lactating. A healthy 2.5 kg male was delivered by elective cesarean section at 37 weeks. He was breastfed for three months. No laronidase was detected in breast milk. The infant never developed anti-laronidase IgM antibodies, never had inhibitory antibody activity in a cellular uptake assay, and always had normal urinary glycosaminoglycan (GAG) levels. No drug-related adverse events were reported. At 2.5 years of age, the boy is healthy with normal growth and development. In this first prospectively monitored mother-infant pair, laronidase during pregnancy and breastfeeding was uneventful.
AuthorsM Castorina, D Antuzzi, S M Richards, G F Cox, Y Xue
JournalClinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 42 Issue 1 Pg. 108-13 ( 2015) ISSN: 0390-6663 [Print] Singapore
PMID25864295 (Publication Type: Clinical Trial, Phase IV, Journal Article, Multicenter Study)
Chemical References
  • Glycosaminoglycans
  • Iduronidase
Topics
  • Adult
  • Breast Feeding
  • Drug Monitoring (methods)
  • Enzyme Replacement Therapy (methods)
  • Female
  • Glycosaminoglycans (urine)
  • Humans
  • Iduronidase (administration & dosage, adverse effects)
  • Infant, Newborn
  • Male
  • Milk, Human (drug effects)
  • Monitoring, Immunologic
  • Mucopolysaccharidosis I (diagnosis, drug therapy, metabolism, physiopathology)
  • Pregnancy
  • Pregnancy Complications (diagnosis, drug therapy, metabolism, physiopathology)
  • Pregnancy Outcome
  • Prospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: