The association between LEPR Q223R polymorphisms and breast cancer risk.

Abstract

Recently, we have read with great interest the article entitled "The association between polymorphisms in the leptin receptor (LEPR) gene and risk of breast cancer: a systematic review and pooled analysis" published online by Wang et al. (Breast Cancer Res Treat 136:231-239, 2012). This article suggests that the A allele of LEPR gene rs1137101 variant was low-penetrant risk factor for developing breast cancer. The result is encouraging. Nevertheless, several key issues are worth noticing.

• Authors: Yadong Wang, Haiyan Yang, Huiyan Gao, Haiyu Wang
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 151 Issue 1 Pg. 1-6 (May 2015) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 25863476 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Comment)

Chemical References

• Receptors, Leptin

Topics

• Breast Neoplasms
• Female
• Genetic Association Studies
• Humans
• Receptors, Leptin (genetics)