Isoniazid induced convulsions at therapeutic dose in an alcoholic and smoker patient.

Abstract

We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.

• Authors: Amol S Aiwale, Utkarsh A Patel, Manish J Barvaliya, Pramod R Jha, Chandrabhanu Tripathi
• Journal: Current drug safety (Curr Drug Saf) Vol. 10 Issue 1 Pg. 94-5 ( 2015) ISSN: 2212-3911 [Electronic] United Arab Emirates
• PMID: 25859682 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• Antitubercular Agents
• Vitamin B Complex
• Pyridoxine
• Isoniazid

Topics

• Adult
• Alcoholism (complications)
• Anticonvulsants (therapeutic use)
• Antitubercular Agents (adverse effects)
• Humans
• Isoniazid (adverse effects)
• Male
• Pyridoxine (therapeutic use)
• Risk Factors
• Seizures (chemically induced, diagnosis, drug therapy)
• Smoking (adverse effects)
• Treatment Outcome
• Tuberculosis, Pulmonary (diagnosis, drug therapy, microbiology)
• Vitamin B Complex (therapeutic use)