[The effects of nicardipine on morphological changes and calcium accumulation during ischemic hypoxia in pyramidal nerve cells in the rat cerebral cortex].
|
| Abstract |
The morphological changes and the calcium accumulation were studied in the rat pyramidal nerve cells which had undergone 5% oxygen inhalation and bilateral carotid artery clamping for 15 minutes, using combined methods of electron and the X-ray microanalytical microscopes. To study the protective effects of nicardipine on brain hypoxia, the same techniques were also used after the inhalation. In the 5% oxygen inhalation group, the chromatin clamping in the nucleus was observed, but calcium ions could not be detected in the neuron using the X-ray microanalytical techniques. In the carotid clamping groups under 5% oxygen inhalation, severe nuclear change and mitochondrial swelling were observed and calcium ions were detected in the mitochondrion. After administrations of nicardipine under 5% oxygen inhalation and under carotid clamping with 5% oxygen, similar morphological changes were recognized by the electron microscope as compared to the non-administration groups. The rate of calcium ion detection was not different significantly (P less than 0.05) between the nicardipine administration and the non-administration groups. It is, therefore, concluded that notable protective effects of nicardipine on ischemic hypoxia were not recognized in this experiment.
|
|---|---|
| Authors | M Yamazaki, M Yamamoto, A Masuda, Y Ito, M Kawahara |
| Journal | Masui. The Japanese journal of anesthesiology (Masui) Vol. 38 Issue 10 Pg. 1264-70 (Oct 1989) ISSN: 0021-4892 [Print] Japan |
| PMID | 2585695 (Publication Type: English Abstract, Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!