Antioxidant and angiostatic effect of Spirulina platensis suspension in complete Freund's adjuvant-induced arthritis in rats.

Abstract

BACKGROUND:

Currently, natural products have built a well-recognized role in the management of many degenerative diseases, mainly rheumatoid arthritis. Recent studies suggest that Spirulina, a unicellular blue-green alga, may have a variety of health benefits and curative properties and is also competent of acting as an anti-inflammatory, antioxidant and recently anti-angiogenic agent. In the present study, the antioxidant and the immunomodulatory effect of Spirulina platensis as well as its anti-angiogenic effect against complete Freund's adjuvant-induced arthritis (AIA) in rat model were tested.

RESULTS:

We found that the development of arthritis was concealed; moreover it successfully inhibited the development of macroscopic as well as microscopic and histopathological lesions in AIA rats when compared to control. Spirulina treated group showed a higher survival rate and moreover, it reduced the clinical score of RA in a dose dependent manner. Furthermore, Spirulina decreased serum levels of COX-2, TNF-α, IL-6, TBARS, VEGF and increased serum levels of GSH compared to the RA non-treated group.

CONCLUSIONS:

The present study concluded that Spirulina is able to restrain the changes produced through adjuvant-induced arthritis. The suppressing effect of Spirulina could be attributed, at least in part, to anti-inflammatory, antioxidant and anti-angiogenic properties.

• Authors: Eman A I Ali, Bassant M Barakat, Ranya Hassan
• Journal: PloS one (PLoS One) Vol. 10 Issue 4 Pg. e0121523 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 25853428 (Publication Type: Journal Article)

Chemical References

• Angiogenesis Inhibitors
• Antioxidants
• Interleukin-6
• Suspensions
• Tumor Necrosis Factor-alpha
• Vascular Endothelial Growth Factor A
• Freund's Adjuvant

Topics

• Angiogenesis Inhibitors (pharmacokinetics, pharmacology, therapeutic use)
• Animals
• Antioxidants (pharmacokinetics, pharmacology, therapeutic use)
• Arthritis, Experimental (blood, chemically induced, drug therapy)
• Biological Availability
• Freund's Adjuvant (adverse effects)
• Immunomodulation (drug effects)
• Interleukin-6 (blood)
• Male
• Rats
• Rats, Wistar
• Spirulina (physiology)
• Suspensions
• Tumor Necrosis Factor-alpha (blood)
• Vascular Endothelial Growth Factor A (blood)