Allograft adenovirus nephritis.

Abstract

We present an uncommon case of allograft adenovirus tubulointerstitial nephritis in a 63-year-old male 6 weeks following cadaveric renal transplantation for end-stage renal failure secondary to hypertensive nephrosclerosis. The patient presented with acute onset of fevers, dysuria, haematuria and diarrhoea with acute graft dysfunction. A renal biopsy demonstrated necrotizing tubulointerstitial nephritis with viral cytopathic changes and no evidence of rejection. Adenovirus was identified as the pathogen. Treatment involved the reduction in the patient's usual immunosuppression, intravenous immunoglobulin, piperacillin-tazobactam and ganciclovir. We present the clinical and pathological findings of necrotizing adenoviral nephropathy, highlighting the importance of considering this diagnosis in renal transplant recipients presenting with interstitial nephritis in the setting of a systemic illness.

• Authors: Kirsty Rady, Giles Walters, Michael Brown, Girish Talaulikar
• Journal: Clinical kidney journal (Clin Kidney J) Vol. 7 Issue 3 Pg. 289-92 (Jun 2014) ISSN: 2048-8505 [Print] England
• PMID: 25852891 (Publication Type: Journal Article)