Abstract | INTRODUCTION: MATERIALS AND METHODS: This double-blinded randomized controlled trial was conducted on 152 girls aged 5 to 12 years with a first acute pyelonephritis episode based on technetium Tc 99m dimercaptosuccinic acid (99mTc-DMSA). They were randomized to receive a 14-day treatment with only antibiotics (control group; n = 76) and 14-day treatment with supplements of vitamin E (intervention group; n = 76) in addition to the antibiotics. Patients' clinical symptoms were monitored for 14 days and urine culture was performed 3 to 4 days and 7 to 10 days after the start of the treatment and its completion, respectively. All of the girls once underwent DMSA scan 4 to 6 months after the treatment. RESULTS: During the follow-up days, the mean frequency of fever (P = .01), urinary frequency (P = .001), urgency (P = .003), dribbling (P = .001), and urinary incontinence (P = .006) were significantly lower in the intervention group compared to the control group. There was no significant difference in the results of urine culture 3 to 4 days after the start of treatment (P = .16) and 7 to 10 days after its termination (P = .37). There was also no significant difference between the results of DMSA scan 4 to 6 months after the start of treatment (P = .31). CONCLUSIONS:
Vitamin E supplementation has a significant effect in ameliorating sign and symptoms of UTI. However, further studies are recommended to confirm these findings.
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Authors | Parsa Yousefichaijan, Manigeh Kahbazi, Sara Rasti, Mohammad Rafeie, Mojtaba Sharafkhah |
Journal | Iranian journal of kidney diseases
(Iran J Kidney Dis)
Vol. 9
Issue 2
Pg. 97-104
(Mar 2015)
ISSN: 1735-8604 [Electronic] Iran |
PMID | 25851287
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Pharmaceutic
- Anti-Bacterial Agents
- Antioxidants
- Vitamin E
- Technetium Tc 99m Dimercaptosuccinic Acid
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Topics |
- Acute Disease
- Adjuvants, Pharmaceutic
(administration & dosage, therapeutic use)
- Anti-Bacterial Agents
(administration & dosage, therapeutic use)
- Antioxidants
(therapeutic use)
- Child
- Child, Preschool
- Dietary Supplements
- Double-Blind Method
- Female
- Follow-Up Studies
- Humans
- Pyelonephritis
(diagnostic imaging, diet therapy, drug therapy, etiology, physiopathology)
- Radionuclide Imaging
- Technetium Tc 99m Dimercaptosuccinic Acid
(metabolism)
- Treatment Outcome
- Urinary Tract Infections
(complications, drug therapy)
- Vitamin E
(administration & dosage, therapeutic use)
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