Favorable effects of superficially deacetylated chitin nanofibrils on the wound healing process.

Abstract

Previous reports indicate that the beneficial effect of chitin nanofibrils (CNFs), and chitosan nanofibrils (CSNFs) for wound healing. In this study, the wound healing effects of superficially deacetylated chitin nanofibrils (SDACNFs) were evaluated using an experimental model. In the experiments using circular excision wound model, SDACNFs induced re-epithelium and proliferation of the fibroblasts and collagen tissue. In the chitin, CNFs, and CSNFs, on the other hand, the e-epithelium and proliferation of the fibroblasts and collagen tissue were not induced perfectly compared with the SDACNFs group. In particular, re-epithelization was observed on day 4 in the only SDACNF group. Moreover, SDACNFs did not induce severe systemic inflammation in the linear incision wound model. The data indicated that SDACNFs effectively induced the proliferation and re-modeling phases compared with chitin, CNFs, and CSNFs in the wound. These data indicate that SDACNFs can be beneficial as a new biomaterial for wound healing.

• Authors: Ryotaro Izumi, Shuntaro Komada, Kosuke Ochi, Lisa Karasawa, Tomohiro Osaki, Yusuke Murahata, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Itoh, Yoshiharu Okamoto, Hironori Izawa, Minoru Morimoto, Hiroyuki Saimoto, Kazuo Azuma, Shinsuke Ifuku
• Journal: Carbohydrate polymers (Carbohydr Polym) Vol. 123 Pg. 461-7 (Jun 05 2015) ISSN: 1879-1344 [Electronic] England
• PMID: 25843880 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Chitin

Topics

• Animals
• Cell Proliferation (drug effects)
• Cells, Cultured
• Chitin (chemistry, pharmacology, therapeutic use)
• Disease Models, Animal
• Fibroblasts (cytology, drug effects, metabolism)
• Nanofibers (chemistry)
• Rats
• Rats, Wistar
• Skin (pathology)
• Wound Healing (drug effects)