The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis.

Abstract

Many studies suggest that catalase C-262T gene polymorphism is associated with cancer risk, but with inconsistent results. This study aimed to summarize the overall association between catalase C-262T polymorphism and cancer risk. Literature search was performed in PubMed, Embase, and other databases, studies regarding the association between catalase C-262T polymorphism and cancer risk were identified, and data were retrieved and analyzed by using Review Manager 5.0.24 and STATA 12.0. A total of 18 publications with 22 case-control studies, including 9777 cancer patients and 12,223 controls, met the inclusion criteria. Meta-analysis results showed significant association between catalase C-262 T polymorphism and cancer risk (TT vs CT + CC: odds ratio [OR] = 1.17, 95% confidence interval [CI] = 1.03-1.31, P = 0.01). Subgroup analyses stratified by cancer types suggested the catalase C-262T polymorphism was significantly associated with an increased prostate cancer risk (TT vs CT + CC: OR = 1.61, 95% CI = 1.17-2.22, P = 0.004); for subgroup analyses stratified by ethnicity, no associations between this polymorphism and Asians or whites were identified (CT + TT vs CC: OR = 1.11, 95% CI = 0.98-1.26, P = 0.09 for whites; OR = 1.19, 95% CI = 0.78-1.80, P = 0.42 for Asians). In summary, the catalase C-262T polymorphism may be a risk factor for cancer with cancer type-specific effects. Further studies should be performed to confirm these findings.

• Authors: Yongchun Shen, Diandian Li, Panwen Tian, Konglong Shen, Jing Zhu, Mei Feng, Chun Wan, Ting Yang, Lei Chen, Fuqiang Wen
• Journal: Medicine (Medicine (Baltimore)) Vol. 94 Issue 13 Pg. e679 (Apr 2015) ISSN: 1536-5964 [Electronic] United States
• PMID: 25837760 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)

Chemical References

• CAT protein, human
• Catalase

Topics

• Catalase
• Genetic Predisposition to Disease
• Genotype
• Humans
• Neoplasms (genetics)
• Polymorphism, Single Nucleotide
• Racial Groups
• Risk Factors