Abstract | BACKGROUND: AIMS: We performed a meta-analysis evaluating the association of hepatitis B and C with anti- phospholipid antibody positivity and with anti- phospholipid antibody-related thrombotic complications. METHODS: RESULTS: 20 studies (2319 cases, 1901 controls) were included. The analyses showed that viral hepatitis is associated with the presence of anti- cardiolipin and anti-β2 glycoprotein-I antibodies. The association with anticardiolipin antibodies was confirmed in both hepatitis B (OR 11.22, 95% CI: 6.68-18.84) and hepatitis C (OR 11.26, 95% CI: 6.82-18.59). Similarly, compared to controls, anti-β2 glycoprotein-I antibodies were found more frequently in hepatitis B (OR 14.07, 95% CI: 3.06-64.66) and hepatitis C (OR 5.64, 95% CI: 1.69-18.77). Moreover, 11 studies (257 cases, 1079 controls) showed a higher prevalence of venous and/or arterial thrombosis in patients with hepatitis and anti- cardiolipin antibody positivity compared hepatitis alone (OR 3.29, 95% CI: 1.79-6.07). This result was consistently confirmed in hepatitis C (OR 3.64, 95% CI: 1.78-7.46) but not in hepatitis B. CONCLUSIONS:
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Authors | Pasquale Ambrosino, Roberta Lupoli, Paolo Tarantino, Alessandro Di Minno, Luciano Tarantino, Matteo Nicola Dario Di Minno |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 47
Issue 6
Pg. 478-87
(Jun 2015)
ISSN: 1878-3562 [Electronic] Netherlands |
PMID | 25835772
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright © 2015 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Antibodies, Antiphospholipid
- Biomarkers
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Topics |
- Antibodies, Antiphospholipid
(blood)
- Biomarkers
(blood)
- Hepatitis B
(blood, complications, immunology)
- Hepatitis C
(blood, complications, immunology)
- Humans
- Regression Analysis
- Thrombosis
(immunology, virology)
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