Invasive pulmonary aspergillosis due to Aspergillus lentulus: Successful treatment of a liver transplant patient.

Abstract

We report a patient with severe invasive pulmonary fungal infection caused by Aspergilllus lentulus, which was identified by genetic analysis, following liver transplantation. The patient was initially suspected to have Aspergilllus fumigatus infection, but worsened clinically despite antifungal therapy appropriate for that species. The patient survived after accurate diagnosis, and detailed drug susceptibility testing led to adequate therapy, demonstrating the importance of performing these investigations for severely immunocompromised patients, including organ transplant recipients.

• Authors: Hisao Yoshida, Masafumi Seki, Takashi Umeyama, Makoto Urai, Yuuki Kinjo, Isao Nishi, Masahiro Toyokawa, Yukihiro Kaneko, Hideaki Ohno, Yoshitsugu Miyazaki, Kazunori Tomono
• Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 21 Issue 6 Pg. 479-81 (Jun 2015) ISSN: 1437-7780 [Electronic] Netherlands
• PMID: 25828927 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antifungal Agents

Topics

• Antifungal Agents (therapeutic use)
• Aspergillus (drug effects)
• Humans
• Immunocompromised Host (drug effects)
• Invasive Pulmonary Aspergillosis (drug therapy, microbiology)
• Liver Transplantation (adverse effects)
• Male
• Middle Aged