Abstract |
This review covers recent progress on the nature of the mitochondrial permeability transition pore (PTP) – a key effector in the mitochondrial pathways to cell death – and on the adaptive responses of tumor cells that desensitize the PTP to Ca(2+) and reactive oxygen species (ROS), thereby playing an important role in the resistance of tumors to cell death. The discovery that the PTP forms from dimers of F- ATP synthase; and the definition of the Ca(2+)- and ROS-dependent signaling pathways affecting the transition of the F- ATP synthase from an energy-conserving to an energy-dissipating device open new perspectives for therapeutic intervention in cancer cells.
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Authors | Andrea Rasola, Paolo Bernardi |
Journal | Cell calcium
(Cell Calcium)
Vol. 58
Issue 1
Pg. 18-26
(Jul 2015)
ISSN: 1532-1991 [Electronic] Netherlands |
PMID | 25828565
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |