Four-year evolution of insulin regimens, glycaemic control, hypoglycaemia and body weight after starting insulin therapy in type 2 diabetes across three continents.

Abstract

AIMS:

It is of interest to understand how insulin therapy currently evolves in clinical practice, in the years after starting insulin in people with type 2 diabetes. We aimed to describe this evolution prospectively over 4 years, to assist health care planning.

METHODS:

People who had started any insulin were identified from 12 countries on three continents. Baseline, then yearly follow-up, data were extracted from clinical records over 4 years.

RESULTS:

Of the 2999 eligible people, 2272 were followed over 4 years. When starting insulin, mean (SD) duration of diabetes was 10.6 (7.8) years, HbA1c 9.5 (2.0)% (80 [22]mmol/mol) and BMI 29.3 (6.3)kg/m(2). Initial insulin therapy was basal 52%, premix 23%, mealtime+basal 14%, mealtime 8% and other 3%; at 4 years, 30%, 25%, 33%, 2% and 5%, respectively, with 5% not on insulin. Insulin dose was 20.2U/day at the start and 45.8U/day at year 4. There were 1258 people (55%) on their original regimen at 4 years, and this percentage differed according to baseline insulin regimen. HbA1c change was -2.0 (2.2)% (-22 [24]mmol/mol) and was similar by final insulin regimen. Hypoglycaemia prevalence was <20% in years 1-4. Body weight change was mostly in year 1, and was very variable, mean +2.7 (7.5)kg at year 4.

CONCLUSION:

Different insulin regimens were started in people with differing characteristics, and they evolved differently; insulin dose, hypoglycaemia and body weight change were diverse and largely independent of regimen.

• Authors: Philip D Home, Marie-Paule Dain, Nick Freemantle, Ryuzo Kawamori, Martin Pfohl, Sandrine Brette, Valérie Pilorget, Werner A Scherbaum, Giacomo Vespasiani, Maya Vincent, Beverley Balkau
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 108 Issue 2 Pg. 350-9 (May 2015) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 25825361 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Hypoglycemic Agents
• Insulin

Topics

• Adult
• Aged
• Blood Glucose (metabolism)
• Body Weight (drug effects)
• Diabetes Mellitus, Type 2 (blood, drug therapy, epidemiology)
• Drug Administration Schedule
• Female
• Follow-Up Studies
• Glycated Hemoglobin (analysis)
• Humans
• Hypoglycemia (blood, chemically induced, epidemiology)
• Hypoglycemic Agents (administration & dosage, adverse effects)
• Insulin (administration & dosage, adverse effects)
• Male
• Middle Aged
• Patient Care Planning (trends)
• Retrospective Studies
• Time Factors