Abstract | RATIONALE: OBJECTIVES: The first step in the estimation of this risk is to determine the prevalence of OSA and OHS in obese individuals with chronic, awake hypoxemia. METHODS: A single-center retrospective cohort study was performed to assess the prevalence and severity of OSA and OHS among obese individuals with hypoxemia. One hundred eighty-four individuals underwent arterial blood gas testing and polysomnography. One hundred fifty-eight of these individuals also had spirometry. MEASUREMENTS AND MAIN RESULTS: The prevalence of OSA was 80%, and the prevalence of OHS was 51%. Chronic obstructive pulmonary disease ( COPD) was confirmed by spirometry in 49% of the cohort, and OSA was found in 69% of those individuals. The severity of hypoxemia in this cohort was not statistically related to COPD, OSA, or OHS. CONCLUSIONS: OSA and OHS are highly prevalent in obese patients with chronic awake hypoxemia, and OSA frequently coexists with COPD. Evaluation of chronic, awake hypoxemia solely based on arterial blood gas measurements and pulmonary function testing is not sufficient to identify OSA and OHS. Further diagnostic sleep testing should be performed to identify those who could benefit from alternative therapies and to avoid potential harm from treatment with supplemental oxygen alone.
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Authors | Marcus Povitz, Matthew T James, Sachin R Pendharkar, Jill Raneri, Patrick J Hanly, Willis H Tsai |
Journal | Annals of the American Thoracic Society
(Ann Am Thorac Soc)
Vol. 12
Issue 6
Pg. 921-7
(Jun 2015)
ISSN: 2325-6621 [Electronic] United States |
PMID | 25822569
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Body Mass Index
- Canada
(epidemiology)
- Cross-Sectional Studies
- Female
- Humans
- Hypoxia
(diagnosis, physiopathology, therapy)
- Male
- Middle Aged
- Obesity
(complications, diagnosis, epidemiology)
- Oxygen Inhalation Therapy
(methods)
- Polysomnography
(methods)
- Prevalence
- Pulmonary Disease, Chronic Obstructive
(diagnosis)
- Respiratory Function Tests
(methods)
- Severity of Illness Index
- Sleep Apnea Syndromes
(diagnosis, epidemiology, etiology, physiopathology, therapy)
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