Effect of Lactobacillus plantarum NCU116 on loperamide-induced constipation in mice.

Abstract

Lactobacillus plantarum, as a probiotic, has many functional properties in human intestinal tract. This study examined the effects of L. plantarum NCU116 on loperamide-induced constipation in a mouse model. Loperamide (5 mg kg(-1)) was injected subcutaneously to induce constipation. Animals were divided to five groups: normal group, constipation group, constipation plus three doses of L. plantarum NCU116 groups (NCU116-L, 10(7) CFU/mL; NCU116-M, 10(8) CFU/mL; NCU116-H, 10(9) CFU/mL; respectively). Mice were treated with the probiotic for 15 d to assess the anti-constipation effects. Fecal parameters, intestinal transit ratio and the production of fecal short chain fatty acids, histological of colon and immunohistochemical in colonic interstitial cells of Cajal (ICC) by c-kit were all improved in L. plantarum NCU116-treated mice as compared to the constipation group. These results demonstrate that L. plantarum NCU116 enhanced gastrointestinal transit and alleviated in mice with loperamide-induced constipation.

• Authors: Chuan Li, Shao-Ping Nie, Ke-Xue Zhu, Tao Xiong, Chang Li, Joshua Gong, Ming-Yong Xie
• Journal: International journal of food sciences and nutrition (Int J Food Sci Nutr) Vol. 66 Issue 5 Pg. 533-8 ( 2015) ISSN: 1465-3478 [Electronic] England
• PMID: 25822005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidiarrheals
• Fatty Acids, Volatile
• Laxatives
• Loperamide

Topics

• Animals
• Antidiarrheals (adverse effects)
• Colon (metabolism, microbiology, pathology)
• Constipation (chemically induced, drug therapy)
• Defecation
• Fatty Acids, Volatile (analysis)
• Feces (chemistry)
• Gastrointestinal Transit
• Lactobacillus plantarum
• Laxatives (therapeutic use)
• Loperamide (adverse effects)
• Male
• Mice
• Probiotics