Royal Jelly and its dual role in TNBS colitis in mice.

Abstract

Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.

• Authors: Luis Paulo Manzo, Felipe Meira de-Faria, Ricardo José Dunder, Eduardo Augusto Rabelo-Socca, Silvio Roberto Consonni, Ana Cristina Alves de Almeida, Alba Regina Monteiro Souza-Brito, Anderson Luiz-Ferreira
• Journal: TheScientificWorldJournal (ScientificWorldJournal) Vol. 2015 Pg. 956235 ( 2015) ISSN: 1537-744X [Electronic] United States
• PMID: 25821860 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Fatty Acids
• NF-kappa B
• Trinitrobenzenesulfonic Acid
• Glutathione Peroxidase
• Ptgs2 protein, mouse
• Cyclooxygenase 2
• Glutathione
• royal jelly

Topics

• Animals
• Anti-Inflammatory Agents (therapeutic use)
• Antioxidants (metabolism, therapeutic use)
• Colitis (diet therapy, metabolism, pathology)
• Cyclooxygenase 2 (metabolism)
• Disease Models, Animal
• Fatty Acids (therapeutic use)
• Female
• Functional Food
• Glutathione (metabolism)
• Glutathione Peroxidase (metabolism)
• Humans
• Mice
• NF-kappa B (metabolism)
• Trinitrobenzenesulfonic Acid (toxicity)