HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Intraocular pressure control with echothiophate iodide in children's eyes with glaucoma after cataract extraction.

AbstractPURPOSE:
To report the intraocular pressure (IOP)-lowering ability and side-effect profile of echothiophate iodide (EI) in the control of glaucoma in aphakic and pseudophakic eyes of children.
METHODS:
The medical records of all aphakic and pseudophakic children treated with EI for IOP lowering after developing glaucoma were retrospectively reviewed.
RESULTS:
A total of 32 eyes of 21 children were included. Mean age at cataract removal was 3.9 months (range, 5 days-2.7 years). Mean age of glaucoma diagnosis was 3.2 years (range, 40 days-12 years). Mean duration from cataract removal and diagnosis of glaucoma was 2.9 years (range, 16 days-12 years). EI reduced IOP in 31 of 32 eyes. Mean baseline IOP (29.1 ± 5.3 mm Hg) dropped to 19.6 ± 6.7 mm Hg. Six eyes had IOP spikes that could not be controlled with other medications when commercial unavailability led to discontinuation of EI. Average duration of use was 3.5 years. Mean final IOP on an average of 2.2 medications was 16.9 ± 5.1 mm Hg 7.9 years following initial glaucoma diagnosis. Four eyes required surgery for uncontrolled IOP. Side-effects included transient redness (3/32 eyes), not necessitating discontinuation of EI.
CONCLUSIONS:
EI lowered IOP to within an acceptable range with no significant adverse events. In several patients it was the only pharmacologic agent that was successful.
AuthorsCourtney L Kraus, Rupal H Trivedi, M Edward Wilson
JournalJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus (J AAPOS) Vol. 19 Issue 2 Pg. 116-8.e1 (Apr 2015) ISSN: 1528-3933 [Electronic] United States
PMID25818282 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 American Association for Pediatric Ophthalmology and Strabismus. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Cholinesterase Inhibitors
  • Echothiophate Iodide
Topics
  • Aphakia, Postcataract (etiology)
  • Cataract (congenital)
  • Cataract Extraction
  • Child
  • Child, Preschool
  • Cholinesterase Inhibitors (adverse effects, therapeutic use)
  • Echothiophate Iodide (adverse effects, therapeutic use)
  • Female
  • Glaucoma (drug therapy, etiology)
  • Humans
  • Infant
  • Intraocular Pressure (drug effects)
  • Male
  • Pseudophakia (etiology)
  • Retrospective Studies
  • Tonometry, Ocular

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: