[A case of ampullary carcinoma progression-free for four years after treatment with TS-1].

Abstract

A 63-year old man was referred to our hospital because of fever, appetite loss, and increased biliary enzyme levels. Upper gastrointestinal endoscopy revealed a tumor in the duodenal papilla, diagnosed as an adenocarcinoma via biopsy, and computed tomography (CT) revealed multiple tumors in the liver. Chemotherapy with TS-1 was initiated based on a diagnosis of ampullary cancer with multiple liver metastases. After TS-1 treatment, the multiple tumors were no longer detectable, and the primary tumor did not increase in size for 4 years. At this time, however, the patient experienced fever, jaundice, and appetite loss. The hepatic mass was not detected via CT or MRI. The primary tumor was determined to be resectable; therefore, we performed subtotal stomach preserving pancreatoduodenectomy. The patient was discharged 55 days after surgery and is alive without recurrence 2 years after surgery.

• Authors: Naoki Mori, Naoki Sakurai, Hajime Iizawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 3 Pg. 367-70 (Mar 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 25812510 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Silicates
• titanium silicide
• Titanium

Topics

• Ampulla of Vater (pathology)
• Disease Progression
• Duodenal Neoplasms (drug therapy, pathology, surgery)
• Humans
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Pancreaticoduodenectomy
• Silicates (therapeutic use)
• Titanium (therapeutic use)