Abstract | OBJECTIVES: MATERIALS AND METHODS: Rabbit models of cardiac arrest were established. After the restoration of spontaneous circulation, 50 rabbits were randomly divided into normothermia and hypothermia groups. The following five time points were selected: before CPR, immediately after CPR, 2 hr after CPR ( hypothermia group reached the target temperature), 14 hr after CPR ( hypothermia group before rewarming), and 24 hr after CPR ( hypothermia group recovered to normal temperature). Glutathione (GSH) concentrations in both the blood and cerebrospinal fluid of the normothermia and hypothermia groups were measured. RESULTS: At 2, 14, and 24 hr after CPR, the GSH concentrations in both the blood and cerebrospinal fluid were significantly higher in the hypothermia group than in the nomorthermia group. CONCLUSION: Mild hypothermia therapy may increase GSH concentrations in rabbit blood and cerebrospinal fluid after CPR as well as promote the recovery of cerebral function.
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Authors | Hui Zhao, Yueliang Chen |
Journal | Iranian journal of basic medical sciences
(Iran J Basic Med Sci)
Vol. 18
Issue 2
Pg. 194-8
(Feb 2015)
ISSN: 2008-3866 [Print] Iran |
PMID | 25810895
(Publication Type: Journal Article)
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