Risk of female breast cancer and serum concentrations of organochlorine pesticides and polychlorinated biphenyls: a case-control study in Tunisia.

Abstract

The aim of this study was to investigate the association between serum concentrations of a group of organochlorine pesticides/polychlorinated biphenyls with xenoestrogenic potential and the risk of breast cancer in a female population from Tunisia. The relationship between serum levels of the pollutants and the risk of cancer was assessed using logistic regression analyses. In the unadjusted models, β-hexachlorocyclohexane (β-HCH), hexachlorobenzene, heptachlor, polychlorinated biphenyl congeners 138, 153, and 180, and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) were positively associated with breast cancer risk. However, when the models were further adjusted for the selected covariates, only β-HCH and p,p'-DDE remained statistically significant, and heptachlor was borderline significant. In addition, analyses using POP concentration tertiles corroborated a positive dose-response relationship that was significant for p,p'-DDE (p-trend=0.020) and borderline significant for heptachlor (p-trend=0.078). A similar trend was also confirmed for β-HCH, in which concentrations≥limit of detection were positively associated with breast cancer risk (vs. concentrations<limit of detection, OR=3.44, p<0.05). Finally, the relative influence of each chemical in the presence of the others was assessed by entering the three chemicals in a single model with all covariates, and only β-HCH remained positively associated with the risk of cancer (OR:1.18, 95%CI: 1.05-1.34). Our findings suggest a potential association between exposure to at least one organochlorine pesticide and breast cancer risk. However, our results should be interpreted with caution, and further research is warranted to confirm these findings.

• Authors: Juan P Arrebola, Hidaya Belhassen, Francisco Artacho-Cordón, Ridha Ghali, Hayet Ghorbel, Hamouda Boussen, Francisco M Perez-Carrascosa, José Expósito, Abderrazek Hedhili, Nicolás Olea
• Journal: The Science of the total environment (Sci Total Environ) Vol. 520 Pg. 106-13 (Jul 01 2015) ISSN: 1879-1026 [Electronic] Netherlands
• PMID: 25804877 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015. Published by Elsevier B.V.

Chemical References

• Environmental Pollutants
• Hydrocarbons, Chlorinated
• Pesticides
• Polychlorinated Biphenyls

Topics

• Adult
• Breast Neoplasms (epidemiology)
• Environmental Exposure (statistics & numerical data)
• Environmental Pollutants (blood)
• Female
• Humans
• Hydrocarbons, Chlorinated (blood)
• Pesticides (blood)
• Polychlorinated Biphenyls (blood)
• Tunisia (epidemiology)