The study was aimed to the optimization of
conservative therapy of
micropenis in hypogonadal men using combination of
traction therapy and
androgen replacment
therapy (ART) with
injections of prolonged
testosterone undecanoate (
Nebido) and to evaluatiom of the safety of ART in terms of the risk of
prostate cancer against the background of combined treatment of
micropenis by both methods within 12 months. The study included 16 men aged 22-62 years with
micropenis and
hypogonadism. 10 men were diagnosed with primary
hypogonadism, 6 men were diagnosed with secondary
hypogonadism without reserve gonadal function; therefore, all 16 patients were treated with
testosterone undecanoate 1000 mg intramuscularly according to the scheme: the second injection 6 weeks after the first injection, then each injection once a 12 weeks, the course of 12 months. During the first 3 months of ART,
hypogonadism in all men was eliminated, but only at 6 month of ART, the length of the penis in the flaccid state at maximum extension increased from 5.8±1.2 to 8.3±1.2 cm (p<0.05), and the length of the erect penis - from 6.8±1.1 to 11.8±0.9 (p<0,05). At the next stage, from the 6th to the 12th month of ART,
traction therapy was simultaneously carried out. At the end of the treatment, the length of the penis in the flaccid state at maximum extension increased by 58% of the original length, and in a state of erection - by 114% (p<0.05). During the 12 months of treatment, prostate volume in all men increased from 3.4±1.2 to 16.3±1.2 (p<0.05), which corresponds to the size of the prostate in healthy men. Total blood PSA level increased from 0.72±0.03 to 1.4±0.05 ng/ml (p<0.05), but it was in the acceptable range of reference values for healthy men during whole period of ART in all patients. Start
therapy with prolonged
testosterone undecanoate for 6 months significantly increases the efficiency of
traction therapy in men with
hypogonadism and
micropenis, but for maintenance of the effect, ART should be continued during all period of treatment.