Abstract | BACKGROUND: ENT surgeons may be the first specialists to encounter and diagnose patients with salivary gland disease. A new entity involving the salivary glands has recently been described of which ENT surgeons need to be aware: immunoglobulin G4 related chronic sclerosing sialadenitis. METHOD: A literature search of Medline, Embase and Cochrane Library databases was performed, using the search terms ' IgG4', 'hyperIgG4 syndrome' and ' IgG4 related chronic sclerosing sialadenitis'. RESULTS: Knowledge concerning immunoglobulin G4 related chronic sclerosing sialadenitis is rapidly increasing. This new entity is part of a fibro-inflammatory corticosteroid-responsive systemic disease ( immunoglobulin G4 related disease) and has been described in almost every organ. Biopsy of the submandibular gland can be diagnostic. However, the diagnosis can easily be overlooked if: clinical suspicion is not high, one is unaware of the classical morphology and/or immunoglobulin G4 staining is not performed. This paper presents a summary of the current understanding of the disease and its management. CONCLUSION: ENT surgeons should be aware of this new disease entity. Patients with systemic disease should be managed under a multidisciplinary team, with input from clinicians who have an interest in such diseases (such as gastroenterologists and rheumatologists), and input from histopathologists and radiologists.
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Authors | E L Culver, A Hunt, E Crewe, K A Shah, P Martinez-Devesa |
Journal | The Journal of laryngology and otology
(J Laryngol Otol)
Vol. 129
Issue 3
Pg. 226-31
(Mar 2015)
ISSN: 1748-5460 [Electronic] England |
PMID | 25797447
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Aged
- Female
- Humans
- Immunoglobulin G
(immunology)
- Male
- Middle Aged
- Sialadenitis
(immunology, pathology)
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