Valeriana officinalis Extracts Ameliorate Neuronal Damage by Suppressing Lipid Peroxidation in the Gerbil Hippocampus Following Transient Cerebral Ischemia.
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| Abstract |
As a medicinal plant, the roots of Valeriana officinalis have been used as a sedative and tranquilizer. In the present study, we evaluated the neuroprotective effects of valerian root extracts (VE) on the hippocampal CA1 region of gerbils after 5 min of transient cerebral ischemia. Gerbils were administered VE orally once a day for 3 weeks, subjected to ischemia/reperfusion injury, and continued on VE for 3 weeks. The administration of 100 mg/kg VE (VE100 group) significantly reduced the ischemia-induced spontaneous motor hyperactivity 1 day after ischemia/reperfusion. Four days after ischemia/reperfusion, animals treated with VE showed abundant cresyl violet-positive neurons in the hippocampal CA1 region when compared to the vehicle or 25 mg/kg VE-treated groups. In addition, the VE treatment markedly decreased microglial activation in the hippocampal CA1 region 4 days after ischemia. Compared to the other groups, the VE100 group showed the lowest level of lipid peroxidation during the first 24 h after ischemia/reperfusion. In summary, the findings in this study suggest that pretreatment with VE has protective effects against ischemic injury in the hippocampal pyramidal neurons by decreasing microglial activation and lipid peroxidation.
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| Authors | Dae Young Yoo, Hyo Young Jung, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Youn-Gil Kwak, Miyoung Yoo, Sanghee Lee, Yeo Sung Yoon, In Koo Hwang |
| Journal | Journal of medicinal food (J Med Food) Vol. 18 Issue 6 Pg. 642-7 (Jun 2015) ISSN: 1557-7600 [Electronic] United States |
| PMID | 25785762 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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