Enriched inhibition of cancer and stem-like cancer cells via STAT-3 modulating niclocelles.

Abstract

We describe for the first time a therapeutic strategy to target stem-like cancer cells via STAT-3 modulation using a nanomedicine approach. Niclocelle, a niclosamide loaded rigid core mixed micelle, was synthesized from a self-assembled well-defined amphiphilic diblock copolymer and an FDA-approved signal transducer and activator of transcription factor 3. Followed by a rigorous physico-chemical characterization, niclocelles were evaluated biologically for cytotoxicity and apoptosis in human melanoma (C32) and breast cancer (MDA-MB231 and MCF-7) cells. Niclocelles were found to selectively reduce the CD44+ stem cell population in C32 cells via STAT-3 modulation.

• Authors: Santosh K Misra, Tor W Jensen, Dipanjan Pan
• Journal: Nanoscale (Nanoscale) Vol. 7 Issue 16 Pg. 7127-32 (Apr 28 2015) ISSN: 2040-3372 [Electronic] England
• PMID: 25785368 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hyaluronan Receptors
• Micelles
• STAT3 Transcription Factor
• STAT3 protein, human
• Niclosamide

Topics

• Apoptosis (drug effects)
• Cell Line, Tumor
• Humans
• Hyaluronan Receptors (metabolism)
• MCF-7 Cells
• Micelles
• Microscopy, Atomic Force
• Microscopy, Electron, Transmission
• Neoplastic Stem Cells (cytology, drug effects, metabolism)
• Niclosamide (chemistry, toxicity)
• STAT3 Transcription Factor (metabolism)
• Signal Transduction (drug effects)