Comparison of Dynamic Phase Enhancement of Hepatocellular Carcinoma Using Gadoxetate Disodium vs Gadobenate Dimeglumine.

Abstract

OBJECTIVE:

To determine the differences in enhancement of hepatocellular carcinoma during the first 5 minutes of postcontrast phases with gadoxetic acid (Gd-EOB-DTPA) vs gadobenate dimeglumine.

METHODS:

Ninety-five cirrhotic patients with hepatocellular carcinoma were examined on a 1.5-T scanner: 74 patients with Gd-BOPTA and 21 patients with Gd-EOB-DTPA. Same magnetic resonance imaging parameters were used for both groups. Gadoxetate isodium was administered at a dose of 0.025 mmol/kg; and Gd-BOPTA, at a dose of 0.1 mmol/kg.

RESULTS:

Mean contrast-to-noise ratios (CNR) were similar in arterial (P = 0.3), portal venous (P = 0.1), and 5-minute delayed phases (P = 0.73). The CNRs of lesions in the Gd-EOB-DTPA group were lower in arterial phase, although this did not reach statistical significance. The CNRs of Gd-EOB-DTPA during the equilibrium phase was higher (P = 0.006).

CONCLUSIONS:

Gadoxetate isodium resulted in lower CNR during the arterial phase and higher CNR during the portal venous, equilibrium, and 5-minute delayed phases compared with gadobenate dimeglumine using the Food and Drug Administration-approved doses; however, overall, there was no statistical significance (P = 0.077).

• Authors: Temel Tirkes, Peter Mehta, Alex M Aisen, Chandana Lall, Fatih Akisik
• Journal: Journal of computer assisted tomography (J Comput Assist Tomogr) 2015 Jul-Aug Vol. 39 Issue 4 Pg. 479-82 ISSN: 1532-3145 [Electronic] United States
• PMID: 25783800 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Contrast Media
• Organometallic Compounds
• gadolinium ethoxybenzyl DTPA
• gadobenic acid
• Meglumine
• Gadolinium DTPA

Topics

• Carcinoma, Hepatocellular (diagnosis)
• Contrast Media
• Female
• Gadolinium DTPA
• Humans
• Image Enhancement (methods)
• Liver (pathology)
• Liver Neoplasms (diagnosis)
• Magnetic Resonance Imaging
• Male
• Meglumine (analogs & derivatives)
• Middle Aged
• Organometallic Compounds
• Reproducibility of Results