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Comparison of lesion improvement in lupoid leishmaniasis patients with two treatment approaches: trichloroacetic Acid and intralesional meglumine antimoniate.

AbstractBACKGROUND:
There are several therapies for treating lupoid leishmaniasis. We compared the effectiveness of intralesional meglumine antimoniate (MA) and topical application of trichloroacetic acid (TCA) 50% solution.
METHODS:
This study was a randomized clinical trial comprising 60 lupoid leishmaniasis patients. The first group received intralesional MA once a week, and the second group was treated once weekly with TCA 50% topical solution. The results were recorded once after 8 weeks and then 3 months after the termination of treatment.
RESULTS:
The total clearance rates after treatment and after the 3-month follow-up were, respectively, 48.1% and 40% in the first group and 44.4% and 36.6% in the second group. There was no significant difference between the two treatment groups (p=.25 and p=.26). In both groups, the most common side effect was scarring.
CONCLUSION:
Having almost the same efficacies, TCA as a topical approach could be as effective as MA in the lupoid leishmaniasis treatment plan.
AuthorsMahnaz Banihashemi, Mohamad Javad Yazdanpanah, Hossein Amirsolymani, Hadis Yousefzadeh
JournalJournal of cutaneous medicine and surgery (J Cutan Med Surg) 2015 Jan-Feb Vol. 19 Issue 1 Pg. 35-9 ISSN: 1203-4754 [Print] United States
PMID25775661 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Copyright© 2014 Canadian Dermatology Association.
Chemical References
  • Antiprotozoal Agents
  • Organometallic Compounds
  • Trichloroacetic Acid
  • Meglumine
  • Meglumine Antimoniate
Topics
  • Adolescent
  • Adult
  • Antiprotozoal Agents (administration & dosage, adverse effects)
  • Child
  • Child, Preschool
  • Humans
  • Injections, Intralesional
  • Leishmaniasis, Cutaneous (drug therapy, pathology)
  • Male
  • Meglumine (administration & dosage, adverse effects)
  • Meglumine Antimoniate
  • Organometallic Compounds (administration & dosage, adverse effects)
  • Skin (pathology)
  • Treatment Outcome
  • Trichloroacetic Acid (administration & dosage, adverse effects)
  • Young Adult

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