Abstract | BACKGROUND: METHODS: This study was a randomized clinical trial comprising 60 lupoid leishmaniasis patients. The first group received intralesional MA once a week, and the second group was treated once weekly with TCA 50% topical solution. The results were recorded once after 8 weeks and then 3 months after the termination of treatment. RESULTS: The total clearance rates after treatment and after the 3-month follow-up were, respectively, 48.1% and 40% in the first group and 44.4% and 36.6% in the second group. There was no significant difference between the two treatment groups (p=.25 and p=.26). In both groups, the most common side effect was scarring. CONCLUSION: Having almost the same efficacies, TCA as a topical approach could be as effective as MA in the lupoid leishmaniasis treatment plan.
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Authors | Mahnaz Banihashemi, Mohamad Javad Yazdanpanah, Hossein Amirsolymani, Hadis Yousefzadeh |
Journal | Journal of cutaneous medicine and surgery
(J Cutan Med Surg)
2015 Jan-Feb
Vol. 19
Issue 1
Pg. 35-9
ISSN: 1203-4754 [Print] United States |
PMID | 25775661
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2014 Canadian Dermatology Association. |
Chemical References |
- Antiprotozoal Agents
- Organometallic Compounds
- Trichloroacetic Acid
- Meglumine
- Meglumine Antimoniate
|
Topics |
- Adolescent
- Adult
- Antiprotozoal Agents
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Humans
- Injections, Intralesional
- Leishmaniasis, Cutaneous
(drug therapy, pathology)
- Male
- Meglumine
(administration & dosage, adverse effects)
- Meglumine Antimoniate
- Organometallic Compounds
(administration & dosage, adverse effects)
- Skin
(pathology)
- Treatment Outcome
- Trichloroacetic Acid
(administration & dosage, adverse effects)
- Young Adult
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