Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation.

Abstract

Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated in multiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of its multiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.

• Authors: Alexander Scholz, Karl H Plate, Yvonne Reiss
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1347 Pg. 45-51 (Jul 2015) ISSN: 1749-6632 [Electronic] United States
• PMID: 25773744 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2015 New York Academy of Sciences.

Chemical References

• ANGPT2 protein, human
• Angiopoietin-2
• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Angiopoietin-2 (metabolism)
• Autoimmune Diseases (immunology)
• Endothelial Cells (immunology)
• Endothelium, Vascular (metabolism)
• Humans
• Inflammation (immunology)
• Leukocytes (immunology)
• Neoplasms (immunology)
• Neovascularization, Physiologic (physiology)
• Sepsis (immunology)
• Signal Transduction
• Vascular Endothelial Growth Factor A (metabolism)