Platelet-rich fibrin with 1% metformin for the treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial.

Abstract

BACKGROUND:

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that releases various growth factors that promote tissue regeneration. Metformin (MF), a member of the biguanide group, has been shown to facilitate osteoblast differentiation and thus may exhibit a favorable effect on alveolar bone. The current study is designed to evaluate the efficacy of open-flap debridement (OFD) combined with PRF, 1% MF gel, and PRF + 1% MF gel in the treatment of intrabony defects (IBDs) in patients with chronic periodontitis (CP).

METHODS:

One hundred twenty patients with single defects were categorized into four treatment groups: OFD alone, OFD with PRF, OFD with 1% MF, and OFD with PRF plus 1% MF. Clinical parameters such as site-specific plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), relative attachment level (RAL), and gingival marginal level (GML) were recorded at baseline (before surgery) and 9 months postoperatively. Percentage radiographic IBD depth reduction was evaluated using computer-aided software at baseline and 9 months.

RESULTS:

PRF, 1% MF, and PRF + 1% MF groups showed significantly more PD reduction and RAL gain than the OFD-only group. Mean PD reduction and mean RAL gain were found to be greater in the PRF + 1% MF group compared to just PRF or MF at 9 months. Furthermore, PRF + 1% MF group sites showed a significantly greater percentage of radiographic defect depth reduction (52.65% ± 0.031%) compared to MF (48.69% ± 0.026%), PRF (48% ± 0.029%), and OFD alone (9.14% ± 0.04%) at 9 months.

CONCLUSION:

The PRF + 1% MF group showed greater improvements in clinical parameters, with greater percentage radiographic defect depth reduction compared to MF, PRF, or OFD alone in treatment of IBDs in patients with CP.

• Authors: A R Pradeep, Kanika Nagpal, Shruti Karvekar, Kaushik Patnaik, Savitha B Naik, C N Guruprasad
• Journal: Journal of periodontology (J Periodontol) Vol. 86 Issue 6 Pg. 729-37 (Jun 2015) ISSN: 1943-3670 [Electronic] United States
• PMID: 25762357 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Fibrin
• Metformin

Topics

• Adult
• Alveolar Bone Loss (diagnostic imaging, surgery)
• Blood Platelets (physiology)
• Chronic Periodontitis (diagnostic imaging, surgery)
• Debridement (methods)
• Dental Plaque Index
• Female
• Fibrin (therapeutic use)
• Follow-Up Studies
• Gingiva (drug effects, pathology)
• Humans
• Longitudinal Studies
• Male
• Metformin (therapeutic use)
• Middle Aged
• Periodontal Attachment Loss (surgery)
• Periodontal Index
• Periodontal Pocket (surgery)
• Surgical Flaps (surgery)
• Treatment Outcome