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Trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum with signet-ring cells, all arising in nevus sebaceus.

Abstract
Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. To our knowledge, this is the first report of signet-ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet-ring cell changes in primary cutaneous tumors.
AuthorsEmilie Dore, Megan H Noe, Brian L Swick
JournalJournal of cutaneous pathology (J Cutan Pathol) Vol. 42 Issue 9 Pg. 645-51 (Sep 2015) ISSN: 1600-0560 [Electronic] United States
PMID25761672 (Publication Type: Case Reports, Journal Article)
Copyright© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Topics
  • Carcinoma, Signet Ring Cell (pathology)
  • Cystadenoma (pathology)
  • Diagnosis, Differential
  • Humans
  • Male
  • Middle Aged
  • Neoplasms, Adnexal and Skin Appendage (pathology)
  • Neoplasms, Multiple Primary (pathology)
  • Nevus, Sebaceous of Jadassohn (pathology)
  • Scalp (pathology)
  • Skin Neoplasms (pathology)
  • Sweat Gland Neoplasms (pathology)

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