Abstract |
Herein, we describe a 63-year-old male with multiple tumors arising within a nevus sebaceus on the posterior scalp. On histopathologic examination, four distinct tumors were identified: trichoblastoma, syringocystadenoma papilliferum, desmoplastic trichilemmoma and tumor of the follicular infundibulum (TFI). Within the TFI component of the nevus sebaceus, there was intracytoplasmic accumulation of eosinophilic keratin, as shown on pancytokeratin-stained sections, imparting a signet-ring appearance to the cells. To our knowledge, this is the first report of signet-ring cells arising within a TFI occurring in a nevus sebaceus. We discuss this case as well as review the literature on multiple tumors arising within nevus sebaceus and signet-ring cell changes in primary cutaneous tumors.
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Authors | Emilie Dore, Megan H Noe, Brian L Swick |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 42
Issue 9
Pg. 645-51
(Sep 2015)
ISSN: 1600-0560 [Electronic] United States |
PMID | 25761672
(Publication Type: Case Reports, Journal Article)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Topics |
- Carcinoma, Signet Ring Cell
(pathology)
- Cystadenoma
(pathology)
- Diagnosis, Differential
- Humans
- Male
- Middle Aged
- Neoplasms, Adnexal and Skin Appendage
(pathology)
- Neoplasms, Multiple Primary
(pathology)
- Nevus, Sebaceous of Jadassohn
(pathology)
- Scalp
(pathology)
- Skin Neoplasms
(pathology)
- Sweat Gland Neoplasms
(pathology)
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