Mucosal
protective agents may improve healing of patients with endoscopic submucosal dissection-induced
ulcers. The present study systematically evaluated published clinical trials to determine whether combined
therapeutic use of mucosal
protective agents and
proton pump inhibitors can improve the outcome of patients with endoscopic submucosal dissection-induced
ulcers compared to treatment with
proton pump inhibitors alone. PubMed, the Cochrane Library, and the Igaku-Chuo-Zasshi database were searched to identify eligible randomized trials for systematic review. We identified 11 randomized trials for inclusion in our study (1,160 patients). Pooled endoscopic submucosal dissection-induced
ulcer healing rates were 45.8% and 34.4% for patients with or without mucosal
protective agents, respectively. The odds ratio was 2.28 (95% confidence interval, 1.57-3.31) with no significant study heterogeneity. In conclusion, the systematic review and meta-analysis showed that the combined
therapeutic use of
proton pump inhibitors and mucosal
protective agents improved healing rates of endoscopic submucosal dissection-induced
ulcers compared to treatment with
proton pump inhibitor monotherapy.