Abstract | AIM: The goal of this study was to determine if the single nucleotide polymorphisms marking potential sensitivity to metformin (MF) correlate with hormone-metabolic status as well as with actual response to MF in postmenopausal cancer patients with or without Type 2 diabetes mellitus and in diabetics without cancer. PATIENTS & METHODS: The carriage of ten different SNPs was evaluated in all patients by PCR, and hormone-metabolic status was estimated by anthropometry, ELISA and enzyme colorimetric assays. The response to daily 1-1.7 g of MF was studied based on hormone-metabolic parameters and indirect end points (endometrium thickness, mammographic breast density). RESULTS & CONCLUSION: The changes in evaluated ' antineoplastic' and metabolic response marker values were seen in 33.3 and 61.8% of the cases, respectively. Several genetic markers were found that showed an inclination to less frequent ' antineoplastic' or more frequent metabolic response to MF which may be helpful in further studies of this drug in cancer patients.
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Authors | Lev M Berstein, Dmitry A Vasilyev, Aglaya G Iyevleva, Marina P Boyarkina, Tatyana E Poroshina, Angela S Khadzhimba, Evgeny N Imyanitov |
Journal | Future oncology (London, England)
(Future Oncol)
Vol. 11
Issue 5
Pg. 759-70
( 2015)
ISSN: 1744-8301 [Electronic] England |
PMID | 25757680
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Hormones
- Hypoglycemic Agents
- Metformin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antimetabolites, Antineoplastic
(pharmacology, therapeutic use)
- Diabetes Mellitus, Type 2
(complications, drug therapy, genetics, metabolism)
- Female
- Genetic Association Studies
- Genotype
- Hormones
(blood, metabolism)
- Humans
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Metformin
(pharmacology, therapeutic use)
- Middle Aged
- Neoplasms
(complications, drug therapy, genetics, metabolism)
- Pharmacogenetics
- Polymorphism, Single Nucleotide
- Postmenopause
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