Abstract | RATIONALE AND OBJECTIVES: Diffuse optical tomography (DOT) is an emerging functional modality, which can reflect tumor metabolic activity and angiogenesis. The purpose of this exploratory study was to correlate the total hemoglobin concentration ( THC) measured by noninvasive DOT with prognostic factors in breast carcinomas. MATERIALS AND METHODS: We prospectively imaged 251 breast carcinomas in 229 consecutive women (mean age, 51.18 ± 12.32 years) using DOT from 2007 to 2010. Tumor angiogenesis and metabolic activity were assessed based on quantitatively measured THC. The THC was correlated with prognostic factors, including tumor size, histopathologic classification, histologic grade, estrogen receptor (ER), progesterone receptor (PR), c-erbB-2, and p53. RESULTS: In univariate analysis, THC was significantly correlated with the following prognostic factors: tumor size (P < .001), histologic grade (P < .001), ER (P < .05), PR (P < .001), and c-erbB-2 (P < .05). THC was not associated with histopathologic classification (P = .170) or p53 (P = .463). On the basis of a stepwise multiple regression analysis, THC of invasive ductal carcinoma was significantly correlated with tumor size (P < .001), histologic grade (P < .001), and PR (P < .05). CONCLUSIONS:
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Authors | Mengsu Xiao, Yuxin Jiang, Qingli Zhu, Shanshan You, Jianchu Li, Hongyan Wang, Xingjian Lai, Jing Zhang, He Liu, Jing Zhang |
Journal | Academic radiology
(Acad Radiol)
Vol. 22
Issue 4
Pg. 439-46
(Apr 2015)
ISSN: 1878-4046 [Electronic] United States |
PMID | 25753593
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 AUR. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Hemoglobins
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(metabolism)
- Breast
(blood supply, metabolism, pathology)
- Breast Neoplasms
(blood supply, diagnostic imaging, metabolism)
- Female
- Hemoglobins
(metabolism)
- Humans
- Middle Aged
- Neovascularization, Pathologic
- Prognosis
- Prospective Studies
- Tomography, Optical
- Ultrasonography, Mammary
- Young Adult
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