Abstract |
Fibrosis has been reported in some patients with immune thrombocytopenia ( ITP) treated with thrombopoietin receptor agonists (TPO-RA). However, fibrosis has also been reported in patients with various stages of ITP, who were TPO-RA treatment-naïve. In our study, we looked for fibrosis in bone marrow trephine biopsies taken at initial diagnosis from 32 adult patients with ITP. Ten of the 32 evaluated samples (31·25%) showed increased reticulin (Grade 1-2 on Bauermeister scale and Grade 0-1 on the European Consensus scale), which showed a positive correlation with ethnicity (0·3%) but did not correlate with disease severity, any clinical features or co-morbidities.
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Authors | Hasan Rizvi, Tom Butler, Mariarita Calaminici, Indraraj U Doobaree, Raghava C Nandigam, Dimitri Bennett, Drew Provan, Adrian C Newland |
Journal | British journal of haematology
(Br J Haematol)
Vol. 169
Issue 4
Pg. 590-4
(May 2015)
ISSN: 1365-2141 [Electronic] England |
PMID | 25753327
(Publication Type: Clinical Trial, Journal Article, Multicenter Study)
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Copyright | © 2015 John Wiley & Sons Ltd. |
Chemical References |
- Receptors, Thrombopoietin
- MPL protein, human
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Humans
- Male
- Middle Aged
- Primary Myelofibrosis
(complications, drug therapy, epidemiology, pathology)
- Purpura, Thrombocytopenic, Idiopathic
(complications, drug therapy, epidemiology, pathology)
- Receptors, Thrombopoietin
(agonists)
- Registries
- Retrospective Studies
- Severity of Illness Index
- United Kingdom
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