Abstract |
Cellular and tissue injury induced by ischemia is often exacerbated by restoring perfusion to the affected organ system. The injury, termed ischemia-reperfusion injury, is mediated in large part by the inflammatory response generated in the setting of reperfusion. Recent research has demonstrated that the administration of hydrogen sulfide as a therapeutic agent in the setting of ischemia-reperfusion can markedly attenuate the inflammatory response with subsequent mitigation of tissue injury and improved function. This beneficial anti-inflammatory effect has been observed in multiple organ systems, subject to ischemia-reperfusion injury, the details of which are the subject of this chapter.
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Authors | Neel R Sodha, Frank W Sellke |
Journal | Methods in enzymology
(Methods Enzymol)
Vol. 555
Pg. 127-44
( 2015)
ISSN: 1557-7988 [Electronic] United States |
PMID | 25747478
(Publication Type: Journal Article)
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Copyright | © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cytokines
- Large-Conductance Calcium-Activated Potassium Channels
- Hydrogen Sulfide
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Cardiovascular System
(drug effects, metabolism, pathology)
- Central Nervous System
(drug effects, metabolism, pathology)
- Cytokines
(biosynthesis)
- Gastrointestinal Tract
(drug effects, metabolism, pathology)
- Hydrogen Sulfide
(pharmacology)
- Inflammation
(drug therapy, metabolism, pathology)
- Large-Conductance Calcium-Activated Potassium Channels
(metabolism)
- Mice
- Rats
- Reperfusion Injury
(drug therapy, metabolism, pathology)
- Respiratory System
(drug effects, metabolism, pathology)
- Swine
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