HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Attenuation of inflammatory responses by hydrogen sulfide (H₂S) in ischemia/reperfusion injury.

Abstract
Cellular and tissue injury induced by ischemia is often exacerbated by restoring perfusion to the affected organ system. The injury, termed ischemia-reperfusion injury, is mediated in large part by the inflammatory response generated in the setting of reperfusion. Recent research has demonstrated that the administration of hydrogen sulfide as a therapeutic agent in the setting of ischemia-reperfusion can markedly attenuate the inflammatory response with subsequent mitigation of tissue injury and improved function. This beneficial anti-inflammatory effect has been observed in multiple organ systems, subject to ischemia-reperfusion injury, the details of which are the subject of this chapter.
AuthorsNeel R Sodha, Frank W Sellke
JournalMethods in enzymology (Methods Enzymol) Vol. 555 Pg. 127-44 ( 2015) ISSN: 1557-7988 [Electronic] United States
PMID25747478 (Publication Type: Journal Article)
Copyright© 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cytokines
  • Large-Conductance Calcium-Activated Potassium Channels
  • Hydrogen Sulfide
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Cardiovascular System (drug effects, metabolism, pathology)
  • Central Nervous System (drug effects, metabolism, pathology)
  • Cytokines (biosynthesis)
  • Gastrointestinal Tract (drug effects, metabolism, pathology)
  • Hydrogen Sulfide (pharmacology)
  • Inflammation (drug therapy, metabolism, pathology)
  • Large-Conductance Calcium-Activated Potassium Channels (metabolism)
  • Mice
  • Rats
  • Reperfusion Injury (drug therapy, metabolism, pathology)
  • Respiratory System (drug effects, metabolism, pathology)
  • Swine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: