Abstract | OBJECTIVE: METHODS: Skeletal muscle biopsies from antisynthetase syndrome-associated myositis and other IIMs from different institutions worldwide were analyzed by histopathology, quantitative PCR, and electron microscopy. RESULTS: CONCLUSION: CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for patients with IIMs, the presence of myonuclear actin filament inclusions accurately identifies patients with antisynthetase syndrome-associated myositis (sensitivity 81%, specificity 100%).
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Authors | Werner Stenzel, Corinna Preuße, Yves Allenbach, Debora Pehl, Reimar Junckerstorff, Frank L Heppner, Kay Nolte, Eleonora Aronica, Veronika Kana, Elisabeth Rushing, Udo Schneider, Kristl G Claeys, Olivier Benveniste, Joachim Weis, Hans H Goebel |
Journal | Neurology
(Neurology)
Vol. 84
Issue 13
Pg. 1346-54
(Mar 31 2015)
ISSN: 1526-632X [Electronic] United States |
PMID | 25746564
(Publication Type: Journal Article)
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Copyright | © 2015 American Academy of Neurology. |
Chemical References |
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Topics |
- Actin Cytoskeleton
(pathology)
- Actins
(metabolism)
- Biopsy
- Humans
- Intranuclear Inclusion Bodies
(pathology)
- Muscle, Skeletal
(pathology, ultrastructure)
- Myositis
(complications, diagnosis, pathology)
- Necrosis
(pathology)
- Sensitivity and Specificity
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