Abstract |
The efficacy of terfenadine in combination with phenylpropanolamine was assessed by comparison with terfenadine alone in a double-blind, parallel group study of 66 patients with nasal birch pollen allergy. The patients were allocated randomly into two groups; 34 patients received terfenadine (60 mg) twice daily and 32 patients a combination tablet containing terfenadine (60 mg) and phenylpropanolamine (50 mg) twice daily for 17 days during the birch pollen season. Nasal symptoms ( sneezing, discharge, itching and blockage) were relieved significantly by both drugs, but control of symptoms was more rapid and better with the terfenadine- phenylpropanolamine combination. Rhinoscopic evaluation of nasal secretion and mucosal swelling showed no differences between the treatment groups. Compared with pre-season values, nasal peak expiratory flow (PEF)-values worsened significantly during the season in the terfenadine, but not in the terfenadine- phenylpropanolamine, group. The general condition of the patients was significantly better in the terfenadine- phenylpropanolamine group. There were no marked side-effects in either group. At the end of the trial some of the patients in both treatment groups still had symptoms; this is apparently due to the long-lasting and severe pollen season. It is concluded that terfenadine combined with phenylpropanolamine gives better control of seasonal allergic rhinitis than terfenadine alone.
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Authors | J Nuutinen, E Holopainen, H Malmberg, J Rinne, J Suonpää, M Silvasti |
Journal | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
(Clin Exp Allergy)
Vol. 19
Issue 6
Pg. 603-8
(Nov 1989)
ISSN: 0954-7894 [Print] England |
PMID | 2574626
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Benzhydryl Compounds
- Histamine H1 Antagonists
- Phenylpropanolamine
- Terfenadine
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Topics |
- Benzhydryl Compounds
(administration & dosage)
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Histamine H1 Antagonists
(administration & dosage)
- Humans
- Male
- Phenylpropanolamine
(administration & dosage)
- Randomized Controlled Trials as Topic
- Rhinitis, Allergic, Seasonal
(drug therapy)
- Terfenadine
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