Potential cognitive decline linked to angiotensin-converting enzyme gene but not hypertension: Evidence from cognitive event-related potentials.

Abstract

OBJECTIVES:

The aims of the present study were to investigate the effect of hypertension and angiotensin-converting enzyme (ACE) genotypes on cognitive event-related potentials (ERPs), and whether the impact of ACE genotypes on P300 is related to the influence of hypertension.

METHODS:

Using the Cognitive Abilities Screening Instrument (CASI), we recruited 97 mentally healthy middle-aged and older adults. Medical histories were collected, and blood pressure, ACE insertion/deletion polymorphisms and ERPs in an auditory oddball task were measured for all participants.

RESULTS:

When the participants were stratified according to the presence or absence of hypertension, there were no differences in CASI score, percentage of ACE genotypes and ERPs. The subjects with the D/D homozygote displayed lower amplitude and longer latency of P300, although there were no differences in CASI score and the percentage of hypertension.

CONCLUSIONS:

The subjects with the D/D genotype tended to have decreased amplitude and prolonged latency of P300 ERPs which reflected subtle cognitive impairment. There were no associations between hypertension, CASI score and P300 measurements.

SIGNIFICANCE:

Using ERPs, potential cognitive decline was linked to ACE genotypes, independently of the effect of hypertension.

• Authors: Li-Min Liou, Yuan-Han Yang, Shiang-Ru Lu, Chung-Yao Hsu, Ching-Kuan Liu, Chiou-Lian Lai
• Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (Clin Neurophysiol) Vol. 126 Issue 12 Pg. 2269-75 (Dec 2015) ISSN: 1872-8952 [Electronic] Netherlands
• PMID: 25743267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Chemical References

• ACE protein, human
• Peptidyl-Dipeptidase A

Topics

• Aged
• Aged, 80 and over
• Cognition (physiology)
• Cognition Disorders (diagnosis, genetics, physiopathology)
• Event-Related Potentials, P300 (genetics)
• Evidence-Based Medicine (methods)
• Female
• Humans
• Hypertension (diagnosis, genetics, physiopathology)
• Male
• Middle Aged
• Neuropsychological Tests
• Peptidyl-Dipeptidase A (genetics)