Comparison of outcomes in patients with probable versus definite cardiac sarcoidosis.

Abstract

Patients with probable cardiac sarcoidosis (CS) who satisfy only clinical cardiac findings for CS are not uncommon. The aim of this study was to compare outcomes between patients with probable CS and those with definite CS treated with steroids. The study population consisted of 101 consecutive patients who satisfied clinical cardiac findings for CS. Patients with definite CS were defined as having histologic or clinical confirmation of CS according to the guidelines and were treated with steroids. Patients with probable CS were defined as having only clinical cardiac findings but not definite CS because of no histologic confirmation or extracardiac sarcoidosis and were not treated with steroids. The end point was major adverse cardiac events. Forty-seven patients had definite CS, and the other 54 had probable CS. Except for serum angiotensin-converting enzyme levels and left ventricular dysfunction, clinical characteristics were similar between the 2 groups. Over a median follow-up period of 15 months, major adverse cardiac events occurred more frequently in patients with probable CS than in those with definite CS (74% vs 53%, p=0.029). The event-free survival rate was worse in patients with probable CS than in those with definite CS (log-rank test, p=0.006). Cox proportional-hazards analysis showed that probable CS was an independent predictor of major adverse cardiac events. In conclusion, outcomes were worse in patients with probable CS than in those with definite CS treated with steroids. The initiation of steroid treatment may be considered for patients who satisfy only clinical cardiac findings for CS.

• Authors: Yoichi Takaya, Kengo F Kusano, Kazufumi Nakamura, Hiroshi Ito
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 115 Issue 9 Pg. 1293-7 (May 01 2015) ISSN: 1879-1913 [Electronic] United States
• PMID: 25743209 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Glucocorticoids
• Peptidyl-Dipeptidase A
• Prednisone

Topics

• Adult
• Aged
• Cardiomyopathies (diagnosis, drug therapy, mortality)
• Disease-Free Survival
• Female
• Follow-Up Studies
• Glucocorticoids (therapeutic use)
• Humans
• Male
• Middle Aged
• Peptidyl-Dipeptidase A (blood)
• Prednisone (therapeutic use)
• Prognosis
• Retrospective Studies
• Sarcoidosis (diagnosis, drug therapy, mortality)
• Stroke Volume