Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia.

Abstract	Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone undecanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymorphisms of CYP2D610. A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D610 genotype frequencies (P>0.05). The follicle-stimulation hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele (C/C) than in the heterozygous variant allele (C/T) or homozygous variant allele (T/T) subgroups (P<0.05). In addition, the percentage of normal morphology was raised at 6 months, and represented the highest percentage in the C/C subgroup (P<0.05). The incidence of spontaneous pregnancy in the C/C subgroup was higher than that in the C/T or T/T subgroups (P<0.01). This study showed that the CYP2D6*10 variant genotype demonstrated worse clinical effects in infertile men with idiopathic oligozoospermia.
Authors	Kai-fa Tang, Yi-li Zhao, Shang-shu Ding, Qi-fei Wu, Xing-yang Wang, Jia-qi Shi, Fa Sun, Jun-ping Xing
Journal	Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 16 Issue 3 Pg. 191-7 (Mar 2015) ISSN: 1862-1783 [Electronic] China
PMID	25743120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Tamoxifen Testosterone Luteinizing Hormone Follicle Stimulating Hormone Cytochrome P-450 CYP2D6 testosterone undecanoate
Topics	Adult Amino Acid Substitution Case-Control Studies Cytochrome P-450 CYP2D6 (genetics, metabolism) Drug Therapy, Combination Female Follicle Stimulating Hormone (blood) Gene Frequency Humans Luteinizing Hormone (blood) Male Oligospermia (drug therapy, enzymology, genetics) Polymorphism, Genetic Polymorphism, Single Nucleotide Pregnancy Sperm Count Sperm Motility (drug effects) Tamoxifen (administration & dosage) Testosterone (administration & dosage, analogs & derivatives, blood) Treatment Outcome Young Adult

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